Dr Radwa Aly Bakry Badawy
2010 Chancellor's Award Winner (Medicine, Dentistry and Health Sciences)
The Chancellor's Prize for Excellence in the PhD Thesis is awarded on an annual basis to four recipients (one each in the Faculties groupings of: Humanities and Creative Arts, Social Sciences, Science and Engineering, and Medicine, Dentistry and Health Sciences).
Dr Radwa Aly Bakry Badawy is the Chancellor's Prize Award Winner in the Medicine, Dentistry and Health Sciences grouping for her thesis entitled: "Cortical excitability and epilepsy; insights into the pathophysiology".
Dr Badawy investigated the role of transcranial magnetic stimulation in epilepsy. She found increased motor cortex excitability in untreated epilepsy patients. Her studies show, for the first time in humans that variation in cortical hyperexcitability is a major mechanism contributing to epilepsy and the risk of seizures.
This work uses transcranial magnetic stimulation to probe the the in vivo inter and peri-ictal balance between excitation and inhibition in the epileptic brain compared to controls and non epileptic events. it demonstrates specific differences in its regulation between generalised and focal seizure disorders and sub-syndromes and change of this balance due to sleep deprivation and the pre and post ictal periods. It reveals a potential physiological measure of responsiveness to antiepileptic medication and provides insights into the mechanism of action of new antiepileptic drugs.